Exosomes - Clinically Tested, Verified Results
Dermatologically Tested
Cruelty-free
Breakthrough Technology
Anti-inflammatory
Anti-aging
Long Shelf Life
Paraben Free
Steroid Free
The Journey from Inception to Perfection
Meet Advancexo
Advancells Group, is one of India’s largest Cell Manufacturing Companies which operate in different verticals to bring cell based solutions closer to our partners, customers and stake holders. Our products have a wide range of applications including regenerative medicine solutions for doctors treating life threatning diseases to ADME and Toxicology studies in the drug discovery process.
Advancexo is a cutting-edge concentrated exosome composition for hair and skin treatments, proudly made in India, pushing the boundaries of active pharmaceutical ingredients, produced in our state-of-the-art, GMP-certified laboratory. This one-of-a-kind API is specifically designed to cater to the needs of cosmetic industries that adhere to the highest quality standards.
We harness the power of billions of exosomes obtained from mesenchymal stem cells (MSC) derived from the human umbilical cord’s Wharton’s Jelly in our API. It possesses the same healing, anti-inflammatory, and regenerating properties as its source, MSCs, without any cells. Our cell-free product is all natural without any added chemicals, which delivers a dose of biologically active ingredients to any formulation.
This advanced lyophilized API has undergone thorough testing, like cytotoxicity and skin path tests, at both preclinical and clinical levels to ensure its safety for dermatological use. Our API is incredibly efficient at tackling a diverse array of skin and hair conditions and can perform wonders beyond expectations. Given its impressive outcomes in “in vitro” and “in vivo” experiments, and its ability to easily integrate into existing formulations, it can easily elevate any cosmetic formulation.
WJ-MSC-derived exosomes, utilized in our API have been included in both the PCPC (Personal Care Products Council) and INCI (International Cosmetic Ingredient Nomenclature Committee) directories, which are highly regarded in the industry. In addition, our trademark is nearly ready for inclusion in the INCL book.
In Vitro Studies
Cell Viability and Proliferation Assay
The proliferation capacity of Advancexo was assessed using a CCK-8 Assay kit on Human Dermal Fibroblasts. Approximately 2 x 104 cells were seeded to each well of a 6-well plate. Negative control was not treated, cells treated with a commercially available fibroblast growth factor (6µg/ml) were used as a positive control. The proliferation capacity was assessed, after trypsinizing and counting cells on the seventh day of expansion. The health of the human dermal fibroblasts post-treatment is displayed below.
In Vitro Cytotoxicity Analysis
The cytotoxicity of Advancexo, using the MTT Tetrazolium Assay was evaluated by the Institute of Industrial Research & Toxicology (IIRT). The study was conducted in compliance with the ISO 10993-5; 2009 (E) guidelines for biological evaluation of medical devices. The mouse fibroblasts L929 cell line was grown as monolayer cultures, maintained with Minimum Essential Medium supplemented with heat-inactivated FBS 10% and 2mM L-Glutamine. The cultured cells were regularly controlled for cell growth and the absence of mycoplasma. The summary of the IIRT Report (No. IIRT/MD/202112/037/CYT) is presented here.
Cytokine Profiling of Advancexo
Advancexo’s cytokine profile was assessed with the help of a Multiplex Assay. The conditioned medium was collected for quantitative estimation of the presence of growth factors on the seventh day of culture. The control was obtained at day zero for baseline value. Advancexo showed several collagen-promoting and anti-inflammatory cytokines.
In Vivo Studies
Innovating Stem Cells to Revolutionize Skin and Hair Care
Presently, cosmetic companies are using active ingredients from plants for the desired effects on skin care; however, it is very important to understand that skin care in our body is naturally controlled with the help of stem cells present within us. Due to ageing, these resident stem cells start losing their capacity to differentiate and regulate skin cells. Geriatric researchers have discovered that multiple factors are responsible for ageing, one of them is inflammatory role played by external stressors like pollution, diseased condition, diet etc.
We have identified the most potent sources of stem cells, isolated from Fetal tissues with in their naïve state. The active ingredients that we isolate from stem cells through unique technology are basically packed controlling codes, secreted by stem cells. Similar codes are inserted in other cells by hijacking them for the production of multiple proteins like collagen, secretion of anti-inflammatory markers for anti-ageing etc. Thus, these active ingredients open the miraculous way towards anti-ageing and longevity. These ingredients are being produced on a mass scale, quality assessed at each step of their development and before the release of the final batch.
Showcasing our Nanowonder to the World
