Sourcing Unique Formulations of Stem Cells for Life with Expertise and Precision

Sourcing Unique Formulations of Stem Cells for Life with Expertise and Precision

Exosomes - Clinically Tested, Verified Results

Dermatologically Tested

Cruelty-free

Breakthrough Technology

Anti-inflammatory

Anti-aging

Long Shelf Life

Paraben Free

Steroid Free

The Journey from Inception to Perfection

In Vitro Studies

Cell Viability and Proliferation Assay

The proliferation capacity of Advancexo was assessed using a CCK-8 Assay kit on Human Dermal Fibroblasts. Approximately 2 x 104 cells were seeded to each well of a 6-well plate. Negative control was not treated, cells treated with a commercially available fibroblast growth factor (6µg/ml) were used as a positive control. The proliferation capacity was assessed, after trypsinizing and counting cells on the seventh day of expansion. The health of the human dermal fibroblasts post-treatment is displayed below.

In Vitro Cytotoxicity Analysis

The cytotoxicity of Advancexo, using the MTT Tetrazolium Assay was evaluated by the Institute of Industrial Research & Toxicology (IIRT). The study was conducted in compliance with the ISO 10993-5; 2009 (E) guidelines for biological evaluation of medical devices. The mouse fibroblasts L929 cell line was grown as monolayer cultures, maintained with Minimum Essential Medium supplemented with heat-inactivated FBS 10% and 2mM L-Glutamine. The cultured cells were regularly controlled for cell growth and the absence of mycoplasma. The summary of the IIRT Report (No. IIRT/MD/202112/037/CYT) is presented here.

Cytokine Profiling of Advancexo

Advancexo’s cytokine profile was assessed with the help of a Multiplex Assay. The conditioned medium was collected for quantitative estimation of the presence of growth factors on the seventh day of culture. The control was obtained at day zero for baseline value. Advancexo showed several collagen-promoting and anti-inflammatory cytokines.

In Vivo Studies

Exosomes are nanovesicles secreted by almost all cells. These cells carry characteristic properties of their source and are capable of delivering cargo between cells. These cargoes contain lipids, proteins, nucleic acids, anti-inflammatory agents and much more, which enables target cells to fight multiple diseases and conditions. As exosomes carry numerous naturally occurring rejuvenating and regenerative agents, without any cells they are a preferred option for cell-free treatment. We have partnered with an external agency to perform clinical tests, where we are testing the efficacy of patch tests, skin sensitivity tests and many more.

Innovating Stem Cells to Revolutionize Skin and Hair Care

Presently, cosmetic companies are using active ingredients from plants for the desired effects on skin care; however, it is very important to understand that skin care in our body is naturally controlled with the help of stem cells present within us. Due to ageing, these resident stem cells start losing their capacity to differentiate and regulate skin cells. Geriatric researchers have discovered that multiple factors are responsible for ageing, one of them is inflammatory role played by external stressors like pollution, diseased condition, diet etc.

We have identified the most potent sources of stem cells, isolated from Fetal tissues with in their naïve state. The active ingredients that we isolate from stem cells through unique technology are basically packed controlling codes, secreted by stem cells. Similar codes are inserted in other cells by hijacking them for the production of multiple proteins like collagen, secretion of anti-inflammatory markers for anti-ageing etc. Thus, these active ingredients open the miraculous way towards anti-ageing and longevity. These ingredients are being produced on a mass scale, quality assessed at each step of their development and before the release of the final batch.

Showcasing our Nanowonder to the World

Advancexo has garnered positive feedback from multiple dermatologists and cosmetic manufacturers at Cosmoprof 2023.

FAQs

Our exosomes are isolated from umbilical cord-derived mesenchymal stem cells. These stem cells are carefully cultured in a controlled environment, and the exosomes they release are then collected and purified for use in skincare and haircare formulations.
Yes, exosome treatments are considered safe. Since exosomes are derived from sourced stem cells, the risk of adverse reactions is minimal. They are also free from ethical concerns associated with live cell usage.
No, AdvanceXO is not intended to be used intravenously. It can only be used for topical applications.
Yes, exosome treatments are generally well-tolerated across different skin types. They are devoid of live cells and are therefore less likely to trigger adverse reactions or allergies.
Absolutely, exosome treatments can complement various dermatological procedures. They are often integrated with treatments like micro-needling, laser therapy, or chemical peels to enhance results and promote faster recovery.