You are currently viewing Plant vs. ASC vs. WJ-MSC Exosomes for Skin Care: A Comparative Analysis

Plant vs. ASC vs. WJ-MSC Exosomes for Skin Care: A Comparative Analysis

Dermatologists across the globe are rapidly incorporating exosome therapy into their practices to achieve unparalleled results in skin rejuvenation and repair. These microscopic messengers are brimming with many bioactive molecules that utilize the power of cellular communication to tap into the skin’s inherent regenerative abilities. Exosome therapy offers a unique way to address a wide range of skin concerns.

The cosmetic industry is currently offering a diverse range of exosomes, either sourced from plants, adipose stem cells (ASC), or Wharton’s jelly mesenchymal stem cell (WJMSC) exosomes. Exosomes from each source have been proven to provide effective results under different circumstances. But it falls on the practicing dermatologists, like yourself, to make a crucial decision.

Which is the most efficacious exosome option for your clients?”

This comprehensive guide will enable you to confidently answer this question and navigate the world of exosome therapy for skin care. We will compare how the source of the exosome affects its ability to be incorporated into your treatment and what factors you must consider before choosing exosomes for your client’s treatment.

Plant exosomes, while promising, have limitations.

Plant exosomes are capturing attention in the world of exosome therapy. They are sourced from plant cells and then mixed with synthetic proteins to provide high efficacy for the treatment. However, before incorporating them into your treatment plans, it is crucial to weigh their potential benefits and inherent limitations when compared to their available alternatives.

Plant vs Human Communication

Plant exosomes are extracted from plants, so they carry plant-specific proteins, metabolites, and signaling molecules. Hence, they cannot effectively communicate with the human cells. However, they do have several chemicals and metabolites required to trigger skin rejuvenation. Still, they might be helpful in providing hydration and antioxidant molecules. But when we look at the big picture, plant exosomes lack the specific bioactive molecules to stimulate cell repair and rejuvenation.

You will ask, why are they becoming so popular then? They are becoming popular because synthetic chemicals can easily manipulate the cargo they carry. They can be loaded with synthetic growth factors, cytokines, and other bioactive molecules to assist in skin rejuvenation. Sure, they will provide results, but no one knows what the long-term effects are.

Because plants lack a complex immune system like humans, the cargo loaded in each exosome is different and inconsistent. This raises the requirement for the clients to undergo quick, repetitive treatments before they see any significant change in their skin appearance. In today’s instant gratification world, if we cannot provide clients with immediate results, they will move on to the next available alternative.

ASC Exosomes: A Potent Ally, But Not Without Limitations


ASC-derived exosomes are the next available alternative for dermatologists when they seek exosome therapy. ASC exosomes are harvested from adult fat tissue. It offers a readily available source of stem cells. These cells churn out exosomes that are filled with human relevant growth factors and bioactive molecules. These exosomes can stimulate collagen synthesis, improve skin texture, and potentially address concerns like wrinkles and fine lines. However, when compared to WJMSC exosomes, they might have limitations in terms of their regenerative potential. Let us look at a few of these limitations:

A potent ally with an imprinted age

ASC-exosomes are adult stem cells. It means they have undergone numerous cell divisions. A larger number of divisions means that their regenerative capacity will be lower when compared to younger stem cells. In other words, we can say that ASC exosomes come with an age, and the age of the source cells is imprinted on them. They do carry a potent number of bioactive molecules, but they fade when we compare them to exosomes harvested from neonatal stem cells.

ASC exosomes have shown effective results when trying to address fine lines, wrinkles, and skin texture. Contrastingly, their results in addressing dark spots, sun spots, hyperpigmentation, and wound healing are, at best, spotty. These exosomes can stimulate collagen synthesis, but they have a limited effect on elastin synthesis. Collagen and elastin together are the miracle workers when trying to give your clients a radiant-looking skin.

Sure, ASC exosomes are more beneficial than the plant exosomes, but they fade in comparison to the WJMSC-derived exosomes. WJMSC-derived exosomes are the best choice for dermatologists because they enable them to offer their clients quick and long-lasting results.

WJ-MSC Exosomes: The Gold Standard in Regenerative Potential

WJMSC derived exosomes reign supreme when it comes to exosome therapy for skin care. These cells are harvested from the umbilical cord, which is extra-embryonic and usually discarded after a child’s birth. Rather than wasting these precious extra-embryonic stem cells, their unparalleled regenerative potential can be transferred to exosomes and help your clients achieve radiant, youthful skin.

The Power of Zero: Unmatched Regenerative Potential


Unlike ASCs, WJMSC are usually classified as “zero-passage” cells. It means they have not undergone any cell division yet. Essentially, they are naive cells that are quite close to their embryonic-like state. Now, because of this, they have an exceptional regenerative capacity that far exceeds that of ASCs.

WJMSC exosomes are brimming with a potent cocktail of growth factors, cytokines, and other bioactive molecules. They have the same potential for repair and rejuvenation as the zero-age stem cells. You can say WJMSC exosomes is a meticulously crafted symphony of bioactive molecules that is ready to help you give your client a glowing skin.

These exosomes carry a wide array of growth factors, cytokines, and antioxidants compared to other exosome sources, and that too in potentially higher concentrations. Their rich blend includes:

  • Epidermal growth factors
  • Transforming growth factor-ß
  • Vascular endothelial growth factors
  • Collagen α1 and α1 chain
  • Cartilage oligomeric matrix protein
  • Contactin-1
  • Cathepsin D

The above list is a small snapshot of what WJMSC exosomes carry with them. Because of such a wide range of rejuvenating biomolecules, they have shown tremendous results for fine lines, wrinkles, skin tightening, wound healing, scar reduction, addressing hyperpigmentation, and overall skin rejuvenation.  


Plant Exosomes

ASC (Adipose-Derived Stem Cell) Exosomes

WJ-MSC (Wharton’s Jelly Mesenchymal Stem Cell) Exosomes



Adult fat cells

Umbilical cord mesenchymal stem cells


Antioxidant and Hydration

Fine line
Skin Texture

Skin pigmentation
Wound healing
Sun spots
Dark spots


Improve hydration‎
Soothe irritation

Improve skin texture and elasticity‎
Reduce wrinkles and fine lines‎

Reduce wrinkles and fine lines‎
Enhance collagen production‎
Improve skin tone and texture
Promote wound healing
Improve skin hydration
Fade scars
Plump skin

Potential Drawbacks

May require frequent application‎ on skin
Synthetically added growth factor
Long-term effects are not clear

Require frequent application on skin
Lower concentration of growth factor than WJMSC exosomes

– More expensive than ASC and Plant exosomes


May be less readily available compared to ASC and WJ-MSC exosomes

Widely available

Widely available

Potential Allergic Reactions

Lower risk of allergic reactions due to plant origin
Sensitive skin might have an allergic reaction to synthetic components

No to minimal side effects

None to minimal risk

Storage and Shelf Life

Shorter shelf life

Stable for storage and transportation within a given temperature range

Stable for long-storage and transportation

Delivery Method

Typically, topical application
Can be added to creams and serums

Typically, topical application
Can be added to creams and serums
Can be subdermal injected into the skin with microneedling or derma roller

Typically, topical application
Can be added to creams and serums
Can be sub dermally injected into the skin with microneedling or derma roller

Invasive Nature

Non-invasive (topical application)

Non-invasive upon topical application
Minimally invasive when used with microneedling or derma roller

Non-invasive upon topical application
Minimally invasive when used with microneedling or derma roller

Recovery Time

No downtime

No downtime for topical application
Minimal downtime for injection

No downtime for topical application
Minimal downtime for injection

Synergistic Effects

May be beneficial when combined with other natural skincare products

May be well-suited for combination with other aesthetic procedures like microneedling

Well-suited for combination with other aesthetic procedures like chemical peel or laser treatments
Can be used as standalone treatment option as well


We can say WJMSC exosomes are the liquid gold for aesthetic dermatology. They are quickly becoming the first go-to option for dermatologists to give their clients a forever young-looking appearance.
Remember, this guide equips you to make an informed decision when choosing an exosome product on the market. Partner with a reputable manufacturer, like Advancexo, who can provide your business with well-researched and clinically validated exosome products.

Embrace the power of exosome therapy and empower your clients to achieve their skincare goals!


Exosomes don’t directly cause hair growth. Instead, they activate hair follicles, which play a role, in the growth of hair. These exosomes contain growth factors, proteins, and nutrients that support the process of hair growth. By providing the growth factors to nourish the hair follicles, exosomes have the potential to aid hair regrowth. The resulting hair from stimulation tends to be thicker. May even help reduce the thinning of hair strands.

Yes, definitely! Exosomes, when used on the scalp, provide nourishment to hair follicles, encouraging them to produce healthier hair. They also support scalp health. Promote the development of blood vessels (known as angiogenesis), enabling the body to deliver more nutrients to the scalp for better hair growth.

It’s perfectly fine to mix exosome therapy with methods for treating hair loss. In fact, there have been instances where combining therapy with other hair loss treatments has yielded superior outcomes. For example, dermatologists are now leaning towards incorporating exosomes following procedures such as laser resurfacing to shorten recovery periods and enhance results.

Exosome hair therapy done using Advancexo has been dermatologically tested on various hair types and is deemed safe for use.

What are the potential side effects and safety considerations of exosome therapy?

Exosome therapy for hair loss is generally safe with side effects. It’s a gentle treatment option. In some instances, some individuals may notice swelling and redness at the application site, but this typically fades away after a short while. To reduce the chances of your clients experiencing any side effects, consider conducting sensitivity tests.