Are you annoyed with dark brown patches on your skin? They might be melasma, a stubborn form of hyperpigmentation that doesn’t appear completely and tends to rebound frequently. Besides sun exposure, melasma can be triggered by hormonal changes and even has genetic roots. While many melasma treatments are available, the pursuit of better options continues.
Among the many scientific innovations, one has stood out- the exosome therapy. It is natural, effective, and backed by years of scientific research. Exosomes are stem cell-derived vesicles that offer the regenerative potential of stem cells in a cell-free manner. Advancexo manufactures these top-notch quality exosomes, extending the Best Melasma Treatment in Delhi. This blog explores melasma treatment along with the benefits of exosome therapy and how Advancexo has been contributing to it.
Topical Melasma Treatment Cream
Several melasma treatment creams are available that reduce melanin production, increase skin cell turnover, or degrade melanin-producing cells. They contain the following active ingredients.
- Hydroquinone: It is considered the gold standard for melasma treatment. It is a hydrophenolic compound that is structurally similar to melanin precursors. Hydroquinone blocks melanin generation by inhibiting the enzyme in melanin synthesis, tyrosinase. It also damages melanocytes- the cells that synthesize melanin. However, its long-term use or high concentration can worsen hyperpigmentation, leading to confetti-like spots or blue-black patches. Owing to these adverse effects, many countries have banned its use.
- Azelaic Acid: It inhibits tyrosine, reduces reactive oxygen species (ROS), and damages melanocytes by suppressing the synthesis of DNA and mitochondrial enzymes.
- Kojic acid: It is a tyrosinase-inhibiting antioxidant that effectively diminishes pigmentation but can cause dermatitis.
- Retinoid: Retinoids, such as tretinoin, enhance skin cell turnover, and retinoic acid alleviates tyrosinase activity. They are used as a triple combination cream with hydroquinone and corticosteroids. However, they can cause side effects such as dryness, redness, and even hyperpigmentation.
- Topical Steroids: These are used in combination with other ingredients but can lead to hypopigmentation, excessive hair growth, irritation, redness, etc.
- Glycolic Acid: It is an alpha-hydroxy acid (AHA) that inhibits tyrosinase and boosts cellular turnover.
- Arbutin: A natural plant product, arbutin, is a derivative of hydroquinone that works by tyrosinase inhibition.
- Ascorbic Acid: Its skin-lightening properties arise from blocking melanin production and UV absorption.
- Niacinamide: A derivative of vitamin B3, niacinamide prevents transfer of melanin pigment to the outer layer of the skin.
- Liquorice Derivatives: Extracted from the root of an herb, these compounds benefit melasma with their anti-inflammatory and tyrosinase-inhibitory properties.
Melasma Treatments
- Chemical Peels: This method removes a layer of skin at different depths, depending on the procedure. This process not only strips the melanin deposits on that layer but also activates repair mechanisms. They enhance the production of collagen and elastin. Based on the chemicals used, these peels are termed as glycolic acid peels, lactic acid peels, Jessner’s solution, trichloroacetic acid (TCA) peels, etc. Jessner’s solution contains lactic acid (AHA), salicylic acid (beta-hydroxy acids or BHA), and resorcinol (a phenolic compound). However, caution is necessary to avoid post-inflammatory hyperpigmentation with this treatment.
- Laser Therapy: Laser therapy has been employed primarily to treat resistant forms of melasma. It lyses the melanin-containing vesicles within melanocytes. However, its impact varies among individuals. The most commonly used lasers include Q-switched lasers, intense pulsed light (IPL), picosecond lasers, ablative fractionated lasers, and non-ablative fractionated lasers. However, the therapy is also associated with recurrence of melasma, inflammation, and hyperpigmentation or hypopigmentation.
- Microneedling: This treatment works on the principle of chemical peels. Instead of removing facial layers, it creates controlled pores within the skin to induce repair mechanisms that stimulate the synthesis of collagen and elastin. Its popularity increased due to its ability to deliver topical formulations into deeper skin layers. Therefore, its application often includes a combination with creams to enhance the overall effects of the treatment.
How Exosome Therapy Treats Melasma?
Exosomes might seem like tiny vesicles, but they contain a plethora of biomolecules—growth factors, RNAs, cytokines, peptides, lipids, etc. These ingredients act on different pathways to drive skin regeneration and treat melasma.
- Turnover: Exosome therapy increases the turnover of all skin cells—fibroblasts in the dermis and keratinocytes in the epidermis—not just the superficial layers.
- Melanin Production: The therapy also inhibits tyrosinase to suppress melanin production.
- Additionally, exosomes also act indirectly on melasma.
- Combat Inflammation: Exosomes are known for enhancing the levels of anti-inflammatory cytokines, which mitigate inflammation, which worsens melasma.
- Scavenge ROS: ROS promotes hyperpigmentation by positively affecting melanin production. Exosomes consume ROS, decreasing their levels and preventing more melanin generation.
- Improve Barrier: The skin barrier is critical for shielding against UV radiation. Exosomes restore the integrity of the barrier by enhancing hyaluronic acid and ceramide levels.
Moreover, exosomes augment the synthesis of collagen and elastin to repair damage caused by UV exposure. They also improve skin health by improving the circulation of nutrients and oxygen.
Why Is Exosome Therapy The Best Treatment for Melasma on Face?
Exosome therapy is a breakthrough in melasma treatment. The reasons are listed below.
- Combination: While each melasma treatment works on a few aspects of the condition, exosomes alone can act on the underlying mechanisms that prevent melanin generation and disperse it from the skin by enhancing turnover.
- Versatile: Exosomes can work synergistically with laser therapy, microneedling, and peels.
- Inflammation: Inflammation is one of the adverse effects of most melasma treatments. Exosomes diminish it. Many studies have reported a significant reduction in inflammation-associated redness in laser treatment after exosome application.
Best Melasma Treatment in Delhi
Advancexo has taken the initiative to manufacture exosomes. Its Skin Rejuve Kit is shaping the best melasma treatment in Delhi. The following attributes distinguish Advancexo and its kit’s exosomes from other products.
- The exosomes in the kit are isolated from umbilical cord mesenchymal stem cells, resulting in higher regenerative potential.
- The kit has been crafted after meticulous research by the Advancexo scientific team.
- Exosomes are enriched in brightening miRNAs and bioactive ingredients to maximize results.
- The company’s GMP-compliance and ISO-certified laboratory assure quality and consistency of the kit.
- The bioactivating solution in the kit contains ingredients that improve overall skin health.
Final Thoughts
Melasma is a difficult condition that can recur even after treatment. While many preventive actions, such as reducing sun exposure or wearing sunscreen, can manage the condition, extensive treatment is often required. The options typically include topical creams or therapies such as laser or chemical peels. However, their adverse effects due to inflammation limit their use and impact.
Exosome therapy is a cutting-edge regenerative solution that mitigates inflammation while also treating melasma. It is an all-in-one solution to diminish hyperpigmentation, re-establish the skin barrier, and drive skin rejuvenation. The result is not just glowing skin but a smooth and supple texture. Advancexo has made the best treatment for melasma on the face, available in Delhi, with its premium-quality Skin Rejuve kit. Packed with skin-brightening ingredients, the kit addresses melasma and holistic skin wellness.
FAQ’s
Q- What is melasma and what causes it?
Melasma is a skin condition characterized by dark brown or grayish patches, typically appearing on the face. It is triggered by factors such as prolonged sun exposure, hormonal changes, pregnancy, oral contraceptives, genetic predisposition, and certain medications. The condition is often stubborn, recurring even after treatment.
Q- How does exosome therapy work for melasma?
Exosome therapy uses stem cell-derived vesicles that deliver biomolecules like growth factors, RNAs, and peptides into the skin. These vesicles inhibit melanin production, promote skin cell turnover, reduce oxidative stress, and repair the skin barrier. Unlike many traditional treatments, exosomes also combat inflammation—one of the root causes of melasma recurrence.
Q- What makes exosome therapy better than other melasma treatments?
Unlike creams, peels, or laser therapies that often target only a few aspects of melasma, exosomes provide a holistic solution. Additionally, they can be combined with treatments like microneedling and laser therapy for enhanced results.
Q- Why choose Advancexo’s Skin Rejuve kit for melasma in Delhi?
Advancexo manufactures premium-quality exosomes derived from umbilical cord mesenchymal stem cells, offering high regenerative potential. Its Skin Rejuve kit is developed through rigorous scientific research, enriched with brightening microRNAs and bioactive ingredients. Produced in GMP-compliant, ISO-certified labs, Advancexo ensures consistency, safety, and effectiveness, making it one of the best melasma treatments available in Delhi.
