Messy and irritating are two words that sum up melasma. It is a form of hyperpigmentation with brown or gray-brown patches as its hallmark. These patches typically appear on cheeks, chin, nose, forehead and upper lip. Unlike the usual hyperpigmentation, melasma is more stubborn, demanding constant care and treatment.
A combination of skincare treatments is recommended to get rid of those patches. But they often reemerge. In 2025, the skincare market is abuzz with a new treatment- the exosome therapy. A therapy that encompasses the effects of different skincare treatments. It is natural, minimally invasive, and versatile. Without doubt, it is the Best Melasma Treatment in Delhi, India, in the year 2025.
Melasma
Melasma is hyperpigmentation, but they are different. How? Well, hyperpigmentation is a broader term for any dark spots on the face, which can occur due to several factors, including age, acne, sun exposure, etc. On the other hand, melasma is distinguishable from hyperpigmentation owing to its specific triggers-
- Hormonal Changes: Pregnant women are most likely to suffer from melasma. Therefore, the condition goes by another name – “mask of pregnancy”. In addition to pregnancy, hormonal changes also occur in people taking oral contraceptives or undergoing hormonal therapies.
- Genetics: Approximately 50% of the melasma patients report a family history of the condition.
- Sun Exposure: UV radiation induces the production of reactive oxygen species (ROS) and skin melanocyte cells. These products, in turn, increase melanin synthesis. Deposition of melanin pigment leads to darker patches on the face.
Research also indicates that people with light-brown or dark skin are prone to developing melasma when exposed to more sunlight. These triggers caution people at higher risk to take preventive measures.
The Available Treatments
A wide variety of treatments are available for melasma, ranging from topical to oral medications:
- Topical Creams: Tretinoin, hydroquinone, and corticosteroids are the key ingredients of topical formulation for treating this condition. They work by increasing the cell turn over and reducing melanin synthesis. However, people could develop hypersensitivity to them, restricting the use of creams and redirecting people to in-clinic procedure.
- Chemical Peels: It involves exfoliation of the top skin layer by a chemical solution. It removes the top pigmented layer and activates the skin healing that grows back is smoother and devoid of dark patches.
- Dermabrasion: It works on the same principle as chemical peels by mechanical removal of skin. Its variant- microdermabrasion is gentler on the face.
- Laser Treatment: Melasma Laser Treatment directs light energy to break the melanin pigment in cells. A healthy skin replaces the treated regions improving skin texture and tone.
- Oral Medications: Tranexamic acid is used for its anti-inflammatory properties and inhibition of melanin production.
All these treatments target different mechanisms of the condition, primarily focusing on skin lightening. But what if there is a way to combine all their effects in one treatment.
Exosome Treatment for Melasma
Exosomes are delivery vehicles of body cells. These naturally occurring vehicles carry and transport diverse bioactive ingredients like RNAs, peptides, and growth factors. Their actions drive cell communication and synchronize their activity. After years of research, scientists have isolated them from Age 0, that is, umbilical cord-derived mesenchymal stem cells, and applied them for cosmetic applications. Stem cell-derived exosome treatment for melasma acts in the following ways to eliminate those dark patches-
- Block Melanin Production: Exosomes inhibit tyrosinase- the key enzyme in melanin synthesis, thus suppressing melanin synthesis.
- Regeneration: Exosomes boost the turnover of cells, which disperse the melanin pigment and lighten the skin tone.
- Anti-inflammation: Exosome therapy enhances the levels of anti-inflammatory cytokines while diminishing pro-inflammatory cytokines, thereby combating inflammatory pathways behind the condition.
- Antioxidation: ROS produced by UV exposure continues to promote melanin synthesis. Exosomes scavenge ROS to prevent both skin darkening and damage.
However, exosome treatment doesn’t stop here. It goes one step further by:
- Stimulating collagen and elastin for firm and smooth skin
- Boosting hyaluronic acid and ceramides for hydration and barrier repair
- Improving blood circulation of nutrient and oxygen supply to nourish the skin
- Modulate immune responses in favor of healing
Scientific research has revealed that melasma is a more complex condition than previously thought. Exosome therapy is a more comprehensive treatment than the available options. It not only lightens the skin but also aims to improve skin health.
Does Exosome Treatment for Melasma Work?
Melasma has complex mechanisms at interplay that cause its reappearance even after successful treatment. The limitations of available medications have redirected the focus on exosome therapy. But the question arises- is it effective? Is it safe?
To answer these questions Chen et al. conducted a study by applying umbilical cord-derived mesenchymal stem cell- exosomes on 60 melasma patients in combination with laser treatment. The team compared the results with patients treated only with laser therapy. Exosome treatment notably improved dark patches in comparison to sole laser treatment. The group also observed the same results by combining exosomes with microneedling. The study supported the effectiveness of exosome treatment for melasma and deemed it safe.
Best Melasma Treatment in Delhi
Indians typically face high UV exposure due to the unique climatic conditions of the country. It makes them more susceptible to melasma and other hyperpigmentation concerns. Therefore, Advancexo has brought the remarkable exosome therapy to India. It has formulated a specialized Exosome Based Skin Rejuve Kit that caters to the distinct needs of Indian skin. Advancexo kit is paving the path for the best melasma treatment in Delhi, and here is why:
- Advancexo has integrated a team of expert scientists who have tweaked each aspect of exosome formulation to perfection.
- The exosomes in the kit are enriched with additional skin brightening RNAs and growth factors to deal with this condition.
- The bioactivating solution of the kit contains ingredients that boost skin health.
- The company follows GMP guidelines in an ISO-certified lab, which is mandatory to manufacture exosomes with assured quality and consistency.
- Their team performs extensive testing on all its batches to ensure delivery of premium-quality products.
- Advancexo exosomes can be combined with laser or microneedling to treat melasma successfully.
Final Words
Melasma involves intricate mechanisms that make its treatment quite difficult. Instead of the present options that address one or two mechanisms, a multifaceted approach seems more appropriate. Exosome therapy has become the preferred treatment for various skin conditions. Its application in melasma is based on its action on not just one but multiple pathways behind the condition. They exploit cell communication and use their biomolecules to target the skin condition at a molecular and cellular level.
Scientific research in its early phase has shown improved results in melasma after exosome treatment. Exosomes can also work in combination with other in-clinic treatments like laser therapy or microneedling. Advancexo is shaping up an ecosystem of the best melasma treatment in Delhi by delivering scientifically formulated Skin Rejuve kit for the Indian market in 2025. With growing clinical studies, positive outcomes, and satisfactory patients, exosomes will take over the cosmetic market in future.
FAQ’s
Q- What does melasma mean?
It is a type of hyperpigmentation marked by the presence of brown or gray-brown patches. It occurs due to excessive production of melanin pigment.
Q- What are the most effective treatments for Melasma?
Highly effective treatments include topical therapies (such as hydroquinone, retinoids, and corticosteroids), chemical peels, dermabrasion, and microdermabrasion, which are all known to help reduce the visible pigmentation and even out skin tone.
Q- What makes melasma different from other types of hyperpigmentation?
General hyperpigmentation can be triggered by things like age, acne, or sun exposure. Melasma Stem Cell Treatment occurs due to hormonal changes (during pregnancy or hormonal therapy) and genetics.
Q- How does exosome therapy improve melasma compared to other treatments?
Exosome therapy for Melasma Stem Cell Treatment delivers bioactive molecules that target multiple pathways involved in pigmentation. It goes beyond traditional treatments by lightening dark patches, promoting skin regeneration, reducing inflammation, neutralizing oxidative stress, and improving overall skin health and hydration.
