The cosmetic market keeps evolving, presenting innovative products every now and then. The latest hair loss therapy that has fascinated people is Exosomes. They are microscopic extracellular nanovesicles that carry biomolecules capable of rejuvenating the scalp from within, driving hair regrowth.
India, known for its biotechnological advancements, is staying ahead with this global trend. In India, Advancexo has taken the charge of formulating exosomes for hair restoration. Their formulation has garnered widespread praise from clinicians and clientele for its efficacy in promoting healthier, fuller hair. Let’s explore why Advancexo is the premium exosome manufacturer in India for hair care solutions.
Exosomes in Hair Care
Exosomes are extracellular vesicles ranging between 30–150 nanometers in diameter . They are tiny cellular messengers that deliver messages from one cell to another. These messages are present in the form of Growth factors, RNA’s, peptides, lipids,signalling molecules etc. When exosomes are applied to the scalp, they initiate cellular processes that are pivotal for hair regeneration and scalp rejuvenation. Here’s how exosomes promote hair growth:
- Exosome-derived growth factors stimulate & proliferate dormant hair follicle stem cells to induce new hair cycles.
- By prolonging the growth phase of the hair cycle, exosomes help produce longer & thicker hair strands.
- Exosomes improve microcirculation in the scalp, which enhances nutrient delivery to hair follicles and supports their sustained growth.
- Chronic inflammation and oxidative damage are major contributors to Hair Loss Exosomes neutralize both, restoring a healthy scalp environment.
This multifaceted regenerative ability positions exosomes as a holistic, cellular-level solution for addressing the underlying causes of hair fall , thinning and loss rather than simply masking the symptoms.
Exosome Manufacturing Process
Unlike synthetic drugs, exosomes are not artificially engineered but are isolated from living biological sources, such as human stem cells. In the aesthetic space, the most reliable and potent source is the human umbilical cord-derived mesenchymal stem cells (UC-MSCs). These stem cells produce exosomes with superior regenerative potential, free from ageing or environmental-related cellular damage. Other sources include adipose tissue stem cells and plant cells. Here is a detailed look into the manufacturing pipeline.
Cell Extraction
The first step is the thorough screening of the biological source of exosomes. For example, every umbilical cord donor undergoes a detailed evaluation that includes testing for infectious diseases, karyotyping analysis and a review of the donor’s medical history. Only after adhering to ethical guidelines, such as getting the donor’s informed consent, is the cord used for isolation. The umbilical cord is transported to a laboratory under cold-chain protocols to maintain its integrity.
Upon arrival, the cord undergoes additional safety screenings for pathogens. Once cleared, mesenchymal stem cells are isolated using sterile enzymatic and mechanical processes. These stem cells are then cultured under tightly regulated aseptic conditions to prepare them for exosome production. Each step of the protocol complies with Good Laboratory Practice (GLP).
Exosome Isolation
As the cells divide, they naturally secrete exosomes into the surrounding culture medium over time. This monitoring of the process optimizes maximum exosome yield without compromising the quality. After collection of a sufficient volume of medium, the next step is to isolate the exosomes. Tangential Flow Filtration is a common method used for this purpose. It filters the exosomes based on their size, separating them from other cellular debris and soluble proteins without damaging their structure.
Quality Control and Characterization
Each batch of exosomes undergoes rigorous quality control testing to validate their identity through flow cytometry, size, and concentration, as well as nanoparticle tracking analysis (NTA) and scanning electron microscopy (SEM). Further tests include ensuring the absence of endotoxins, mycoplasma,fungi and other bacterial contaminants.
Storage
After successful testing, the last step involves optimization of the storage conditions to preserve exosome activity and shelf-life.
Exosome Manufacturing Company in India: What to Consider?
While several companies are producing exosomes, not all maintain the same standards of quality. Consider the following before choosing the exosome manufacturing company in India:
Laboratory Infrastructure
Exosome production involves working with cells. Thus, it requires a sterile environment and a well-equipped laboratory facility.
Scientific Expertise
Exosomes are a scientific innovation that emphasizes the incorporation of scientists with expertise in the area. This ensures proper protocol optimization for an assured quality product.
Regulatory Compliance
Manufacturers should adhere to GMP (Good Manufacturing Practices) and ethical guidelines for maintaining quality.
Rigorous Testing
Stringent testing of the product affirms the quality of the product and the absence of any contaminants.
To ensure the reliability of exosome formulations, check for certificates like ISO, GMP, CoA, etc. Moreover, the manufacturer’s in-house laboratory indicates that it has invested in its own scientific research and has a dedication towards further improvements.
Advancexo: Premium Exosome Manufacturer In India
Advancexo has established itself in the Indian aesthetic market. Its focus on scientific integrity and high quality is evident in the following.
In-House Lab
Advancexo is India’s own homegrown brand of exosomes. It stands out in the market as the premium exosome manufacturer for hair care for the following reasons.
GMP-Compliance
Advancexo has earned a cGMP certificate for following regulatory guidelines, which demonstrates that the product is high-quality and consistent within batches.
Scientific Excellence
Advancexo’s team comprises scientists with experience in stem cell research and molecular biology. They have refined every step of the manufacturing process.
Uniformity
All exosomes are sourced from well-screened UC-MSCs. Their regenerative capability is higher than any other source, and there is minimal batch-to-batch variability.
Multi-Stage Testing
The product undergoes testing at different stages of development. The formulation has also received third-party quality certifications, adding an extra layer of credibility. All products are accompanied by a CoA, confirming exosome concentration and purity.
Long-Term Stability
Advancexo’s formulation maintains stability for up to 12 months and a prolonged shelf-life without compromising therapeutic potential.
Advancexo Hair Rejuve Kit
The flagship product, the Advancexo Hair Rejuve Kit, brings clinical exosome therapy to dermatology clinics and aesthetic centers across India. It contains 10 billion exosomes per kit and offers a comprehensive solution for hair regrowth. Its key features are:
- Chemical-Free: The formulation is free from parabens, sulfates, or synthetic additives—making it ideal for sensitive scalps.
- Bioactivating Solution: The exosomes are to be dissolved in a bioactivating solution enriched with vitamins, minerals, amino acids, and coenzymes that nourish and stimulate the scalp.
Conclusion
Exosome therapy is a groundbreaking development in a non-surgical hair restoration solution. It addresses hair loss therapy at a cellular level, offering a highly effective alternative to conventional treatments.
Advancexo is shaping the future of the exosome landscape in India with its Hair Rejuve kit. Their clinical-grade production standards have gained them nationwide preference. Integrating exosomes into modern hair treatments rejuvenates the scalp and revitalises the hair follicles. Advancexo’s Hair Rejuve Kit, in particular, has developed a specialized kit to cater to different hair problems (hair loss and hair thinning) to deliver noticeable improvements in hair growth.
FAQ’s
Q- What makes Advancexo’s exosome formulation stand out?
Advancexo’s exosome formulation is derived from human umbilical cord mesenchymal stem cells (UC-MSCs), which are known for their high regenerative potential. The formulation is chemical-free, enriched with bioactivating nutrients, and has a shelf-life of up to 12 months.
Q- Are exosome treatments safe for all hair types and scalp conditions?
Yes, exosome treatments are generally safe for all hair types and most scalp conditions, provided they are formulated and tested properly. Advancexo follows stringent GMP guidelines, ISO certifications, and third-party testing to ensure purity, sterility, and safety.
Q- How soon can I expect to see results from the Advancexo Hair Rejuve Kit?
Results may vary from person to person, but users typically start noticing improvements in hair texture, density, and scalp health within a few weeks to months of consistent use.
Q- Why are UC-MSCs considered the best source for exosome therapy?
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are young, undamaged, and ethically sourced, making them an ideal source for high-quality exosomes. Unlike cells from aged tissues (like adipose, bone marrow ), UC-MSCs offer uniformity, greater regenerative capacity, and are free from environmental and age-related toxins.
