In this chaotic life, exposure to UV radiation, pollution & stress, has become a part of our daily routine. UV exposure noticeably darkens the skin, causing hyperpigmentation. The dark spots and uneven skin tone steal the original glow and turn down a person’s visual appeal. The hyperpigmentation worsens for people already suffering from melasma and post-inflammatory hyperpigmentation. With age, UV damage accumulates making these dark patches even more prominent.
Are you also struggling with dark spots? The constant UV exposure has made your skin dull and dry. A solution that can return the brightness of the skin and also restore its youthful texture is the intended goal.
Scientists have researched extensively and crafted an extraordinary therapy – Advancexo Exosome Therapy for skin rejuvenation. This exosome therapy is infused with regenerative abilities and an effective treatment for hyperpigmentation.
Decoding Hyperpigmentation
Before exploring this exosome therapy, let’s understand what hyperpigmentation is and how UV radiation causes hyperpigmentation.
Hyperpigmentation is the accumulation of melanin pigment in the outer skin layer in higher amounts.
Our skin has melanocytes, specialized cells that form melanin pigment. This pigment is formed from tyrosine via a multistep process and is transported from melanocytes to the keratinocytes, the cells present in the outer layer of skin. UV radiation triggers diverse cellular processes that induce melanin synthesis. Melanin has an extraordinary capacity of absorbing UV radiation and scavenging the UV-induced reactive oxygen species (ROS). Melanin is basically a photo protectant that prevents UV damage. Although cells produce melanin to counter the negative impact of UV radiation, it has the downside of causing hyperpigmentation when present in excessive amounts.
Exosomes: The Power of Regeneration
Cells release exosomes to communicate with the surrounding cells. They acquire the characteristics of their parent cell. Thus, stem cell-derived exosomes possess the regenerative potential of stem cells. The exosome therapy provides the cell-free alternative for the regeneration process. These tiny particles only range from 30-150 nm, but have enormous capacity to alter cellular events.
Cells package these spherical particles with biomolecules including RNAs, lipids, proteins, growth factors, signaling molecules and peptides. After entering the surrounding cells, exosomes deliver this package inside cells that influence various signaling pathways to modulate cellular behavior.
Melanin Synthesis: UV exposure prompts the keratinocytes to form α-melanocyte stimulating hormone (α-MSH). This α-MSH binds to melanocytes and activates microphthalmia-associated transcription factor (MITF). The MITF is responsible for the synthesis of enzymes involved in melanin production. Exosomes block the melanin synthesis by inhibiting the MITF-dependent tyrosinase enzyme, a key enzyme in melanin production.
Antioxidant Effect: UV radiation also stimulates the generation of ROS. ROS, particularly H2O2 activate the enzyme that converts phenylalanine into tyrosine. In addition, ROS stimulate MITF and tyrosinase as well. Exosomes consume these ROS and deter their subsequent downstream pathways.
Anti-Inflammation Effect: Inflammation is an abnormal immune response of the body that involves chemical mediators or cytokines. It appears as swelling, pain or redness. The inflammatory cytokines promote melanocyte proliferation and the formation of melanin synthesis enzymes. Exosomes switch the production of cytokines from pro-inflammatory to anti-inflammatory, thus reducing inflammation. They also regulate the immune response to focus towards repairing processes.
Cell Proliferation: All the events that UV exposure triggers lead to cell damage and subsequent cell death that further deteriorate the skin texture. Exosomes also increase the turnover of cells. It improves the skin texture and also disperses the pigment, thus lightening the skin.
Exosomes: Skin Revitalization Therapy
But these exosomes have an added bonus. They not only work on hyperpigmentation but also on other adverse effects on skin, whether they occurred due to UV exposure or age.
The UV-generated ROS also degrade the extracellular matrix (ECM) and damage the cells that produce ECM. Age also results in ECM disorganization. Collectively, they lead to a notable loss of strength, elasticity, firmness, and hydration of the skin, making it dull and dry. However, exosomes proliferate the ECM-producing cells. They boost collagen and elastin levels that enhance the skin barrier with more strength and elasticity. Exosomes also elevate the quantity of hyaluronic acid and ceramides. Both of them lock in the moisture and hydrate your skin. This rejuvenated barrier protects from further harm. Furthermore, exosomes also promote the formation of blood vessels. The higher number of vessels also augments the nutrients and oxygen supply to the cells. ECM maintenance and increased vessels improve the health at a cellular level, thereby elevating the overall look with anti-aging .
Unveiling The Advancexo Exosome Therapy
In view of the benefits of exosomes, Advancexo has formulated a kit- Skin Rejuve Kit to address hyperpigmentation as well as skin health. It provides several advantages that result in glowing and vibrant skin.
- Advancexo exosomes are derived from a human source that are easily recognizable by human skin cells to fully exert their effects.
- The aging process affects the cells and their products. Considering this fact, the scientific team of Advancexo has extracted exosomes from umbilical cord mesenchymal stem cells. These are day 0 cells and do not have any aging effects.
- The Advancexo exosome kit has two vials: exosomes and a bioactivating solution. The bioactivating solution has vitamins, coenzymes, and amino acids that further boost your skin health.
- Their team of experienced scientists has packed the exosomes with brightening miRNAs for enhanced effects on hyperpigmentation.
- These exosomes are extracted, purified, and tested in a cruelty-free manner.
- Vitamin C is known for its ability to reduce melanin and ROS-induced oxidative stress. Exosomes also increase the levels of vitamin C in skin cells.
- They are also empowered with additional growth factors, miRNAs, proteins, and peptides that confer anti-inflammation, cell proliferation, anti-aging, and barrier restoration properties, thus refining the general appearance of the skin.
Safety of Exosome Therapy
As we have discussed, the exosome treatment has numerous benefits. However, the question arises whether their application will have any undesired effects.
No. Exosomes are naturally occurring components of the body that all cells secrete. They also act on the cells in a well-balanced and regulated manner, thereby avoiding any uncontrolled or undesired responses. Also, Advancexo has ensured that their kit has no harsh chemicals like parabens and steroids, thus ensuring a 100% natural product. Through all the above factors, Advancexo has assured that their application has no adverse effects on skin. Advancexo exosome treatment has also received scientific validation and clinical approval from dermatologists & Plastic surgeons. Advancexo exosomes have prolonged shelf life and stability at room temperature, which ensure their efficacy for longer periods. The exosome therapy can be combined with other treatments such as microneedling, laser therapy, topical formulations, and injectables.
Conclusion
Nowadays, dark blotchy spots and uneven skin tone are frequent skin issues owing to regular UV exposure. Exosome therapy is a new-age technology that has been reshaping skin rejuvenation treatments. With its multi-faceted approach, this therapy has potential benefits on hyperpigmentation as well as on skin health as a whole. They not only reduce the damage, but also prevent further harm and restore the skin to a healthy state. Therefore, one gets brighter skin after treatment, along with enhanced smoothness and firmness.
Considering its numerous advantages, Advancexo has specially availed this revolutionizing technology in a Skin-Rejuve Kit to cater to multiple skin problems, including hyperpigmentation. Their exosomes are dermatologically approved and are even enriched with more growth factors, peptides, proteins, and RNAs for augmented effects. The Advancexo exosome kit is not just a hyperpigmentation treatment but a complete skin rejuvenation package.
FAQs
Hyperpigmentation is the excessive accumulation of melanin pigment in skin due to UV exposure. It appears as dark spots and uneven skin tone.
Exosomes inhibit the enzyme involved in melanin synthesis, scavenge reactive oxygen species, regulate inflammation, increase cell proliferation, and increase ascorbic acid levels to reduce hyperpigmentation.
Yes. Exosome therapy is an anti-aging therapy. It acts on age-induced effects such as fine lines, open pores, dry skin, etc.
Advancexo exosomes have been extracted from umbilical cord-derived mesenchymal stem cells (MSCs) due to their anti-inflammatory and antioxidant properties.
