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Recover the Lost Beauty with the Exosome Therapy on This Valentine Day

Nowadays, stress and environmental triggers are adversely affecting the overall health of a person. These stressors also negatively impact skin and hair, the crucial components of an individual’s aesthetics. Presently, the topical formulations, oral medications, and even invasive surgical procedures are employed to treat hair and skin disorders, but are met with limited success. 

Exosome Therapy is a revolutionary technology with substantial applications in cosmetic treatment. Their repair and regenerative properties restore the tissue structure and function. They can be administered by microneedling- a minimally invasive procedure. The stem cell-derived exosomes have demonstrated remarkable outcomes in hair and skin therapy with notable patient satisfaction. Let’s explore the world of exosomes to fulfill your Valentine’s Day goals. 

What are exosomes?

Exosomes are the small vesicles released by the cells to communicate through signaling to neighboring cells. They are packed with the cellular machinery, such as messenger RNA, miRNA, growth factors, etc., carrying external signals. These signals are identified by the neighboring cells, which then hijack secreted exosomes, which get incorporated into the host cells, and direct them for further gene expression, protein synthesis, and secretion of cytokines. Scientists have also packaged these nano-sized vesicles with exogenous biomolecules and drugs to promote targeted actions, deeming them ideal candidates for drug delivery.

MSCs are known stem cell therapeutics for the treatment of numerous disorders. In addition to differentiation into the resident tissue cells, they also induce regenerative properties via paracrine signaling. Therefore, MSC-derived exosomes have been extensively studied and found to exert regenerative effects similar to those of MSCs. Their application has been especially favorable in the dermatology field with pronounced effects on skin and hair revitalization.

Benefits of exosomes

Exosomes mediate their effects by acting on multiple pathways in the surrounding tissue cells.

  • Cell proliferation: It is studied that due to external stressors and a challenged microenvironment, cells often undergo untimely senescence and have reduced proliferation capacity. However, exosome therapy can help them to create a good microenvironment, which supports cellular proliferation, reduces secretion of inflammatory markers, and avoid untimely apoptosis. 
  • Free oxygen radicals: Diseases and environmental triggers increase the concentration of free oxygen radicals. These radicals cause DNA and protein damage as well as augment the inflammatory mediators. Exosomes curb the levels of free oxygen radicals and their subsequent effects.
  • Anti-inflammation: Inflammation is part of the body’s immune response. But abnormal or chronic inflammation causes harm to normal tissue. In addition to controlling free oxygen radical levels, exosomes also stimulate anti-inflammatory cytokines and inhibit proinflammatory cytokines, preventing further injury.
  • Angiogenesis: Blood vessels regulate the blood flow to tissues. Exosomes recruit endothelial progenitors to form blood vessels by angiogenesis process and increase the blood supply to tissue vital for tissue rejuvenation.

Who needs exosome treatment?

The natural healing ability of exosome therapy has made it a preferential treatment modality over conventional treatments. The treatment is particularly beneficial for people with hair and skin disorders. Individuals dealing with severe skin conditions like melasma, vitiligo, scleroderma, etc., or desiring aesthetic treatment for reducing hyperpigmentation, acne scars, wrinkles, fine lines, and skin abrasions can avail the exosome therapy. Moreover, individuals experiencing hair thinning, excessive hair loss, alopecia, and low hair density can also reap the benefits of exosome treatment. Exosome treatment is also advantageous for people facing more than one disorder. The therapy provides visible results with superior patient satisfaction.

Skin Revitalization Effects of Exosomes

Hyperpigmentation: Hyperpigmentation results from excessive melanin production by melanocytes. Exosome treatments have been shown to mitigate melanin production by inhibiting the tyrosinase enzyme required for melanin production.

Scar Removal: Pathological scars have a slow healing process and show incomplete recovery. Exosome therapy promotes keratinocyte proliferation, induces anti-inflammation, stimulates collagen deposition to stimulate scar recovery, and minimizes the scar width.

Anti-Aging: Exosomes cause proliferation and migration of keratinocytes and fibroblasts, enhance angiogenesis, and promote the deposition of collagen and elastin. It restores the skin barrier along with its firmness and elasticity.

Hair Therapy

Hair Loss: Exosome treatment increases the proliferation and migration of dermal papillary cells while also increasing the proliferation and differentiation of hair shaft stem cells. They also stimulate the formation of new hair follicles and prolong the anagen/growth phase, generating new hair shafts. Moreover, they also elongate the hair shaft and hair follicle. Their anti-inflammatory properties lower the levels of free oxygen radicals. Hence, they alleviate follicle miniaturization and augment the hair number, coverage, and density.

Hair Thinning: Exosome therapy also decreases the apoptosis of dermal papillary cells while increasing the diameter of the hair bulb. They shift the hair growth cycle from the telogen/resting phase with dormant growth to the anagen/growth phase, where new hair shafts form. They also promote the secretion of growth factors IGF, HGF, and KGF to induce cell proliferation. Through all these mechanisms, exosomes increase the weight and thickness of hair.

Better than conventional therapy

There are several medications available for skin and hair treatment. So why should one choose exosome therapy over the conventional drugs?

  • The drugs only affect one underlying mechanism, whereas exosome treatment act on a multitude of pathways that avoid further damage and cause tissue repair.
  • Therapeutic drugs can prevent further tissue destruction, but provide unfavorable results for reducing the existing damage. However, exosomes induce tissue recovery and effectively diminish the deteriorated tissue, resulting in satisfactory patient outcomes.
  • Medications have potential side effects, whereas safety studies on exosome therapy have not demonstrated any adverse events after exosome administration.
  • Drugs are synthetic in nature. But exosomes are already present in individuals and are natural products that stem cells secrete.
  • Exosomes can be additionally packaged with biological moieties such as growth factors, miRNAs, proteins, and peptides to enhance the desired effect. However, drugs lack this ability. Multiple drug administrations are possible, but also induce potential side effects.

Why Advancexo?

Exosome therapy is a cutting-edge technology that provides multiple benefits. Advancexo has pioneered the manufacturing process of exosomes. The following reasons detail why to select Advancexo as your partner.

  • A team of highly qualified personnel extracts these exosomes and performs robust quality checks.
  • We use Wharton’s jelly MSCs to prepare exosomes, which have profound effects on tissue restoration.
  • Each vial has a billion exosomes with proven efficacy.
  • These exosomes have long-term stability and enhanced shelf life at room temperature, offering lasting efficacy.
  • Our team has also packaged them with 65 miRNAs and 165 peptides and proteins to exert anti-aging, brightening, anti-inflammatory, cell proliferative, barrier maintenance, and wound healing effects.

Conclusion

The current medications for skin and hair treatment act on specific pathways to the deteriorating effects of disorders. But they show minimal impact, not to mention ample side effects associated with these synthetic drugs. Stem cells can differentiate into tissue cells. However, the underlying immune rejection risks restrict their use. The exosomes extracted from MSCs have shown their potential regarding such treatments. They acquire the paracrine signaling characteristics from their parent MSCs in the form of growth factors, miRNAs, proteins, etc. Through the paracrine signaling, MSC exosomes induce tissue regeneration in the neighboring cells. Moreover, they lack cell therapy-related adverse effects while needing easy storage and transportation facilities. Advancexo provides the exosomes with additional enrichment with biomolecules to enhance their impact for treatment. Our team isolates and characterizes them thoroughly to ensure their quality and functioning. This Valentine’s day, gift yourself and your loved ones the opportunity to restore the lost beauty with Advancexo hair and skin packages.

FAQs

Yes, exosomes restores the skin barrier and also has brightening effects on skin. Studies have shown that exosomes increase the number of hairs, their density, and coverage. They also significantly reduce hair thinning.

Yes. Drugs act on limited pathways without any tissue restoration ability, leading to minimal decrease in damage. But exosomes work on numerous pathways that cause tissue repair and recovery.

Advancexo provides quality-assured exosomes, which are packaged with numerous biomolecules that boost the efficacy of exosomes by demonstrating anti-inflammatory, anti-aging, and cell proliferation effects on tissue.

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