Is hair thinning worrying you? It has also affected millions of people on a global level. Hair reflects the identity of people and is an integral part of a person’s appearance. Hair thinning deeply influences a person’s self-image, lowering their self-esteem. The psychosocial impact extends even to professional and personal life.
From age, stress, nutrition to diseases and hormones, numerous factors can cause this. The underlying mechanisms interplay in a complex and dynamic manner, rendering the prevention and treatment a challenging task.
Therefore, the issue requires a transformative therapy that works in-depth on different aspects of the disorder. Keeping that in mind, the scientific community has launched exosome therapy for hair thinning. The hair follicle regeneration with exosomes results in increased hair density with longer and stronger hair.
The Root Causes of Hair Thinning
Genetic Trait: An individual could be more prone to hair shedding and loss owing to an inherited genetic trait.
Hormonal Imbalance: Hormonal imbalance influences hair growth, especially androgens. Hormonal changes after childbirth also affect hair formation in women.
Nutritional Deficiency: Lack of nutrition in modern-era dietary habits is common and causes substantial thinning.
Age: Age declines the number of stem cells, adversely impacting hair development.
Stress: Stress increases the cortisol levels that negatively influence hair growth.
Medications: Certain drugs, such as anticoagulants, antiretroviral, antihypertensives, statins, etc., also drive hair loss.
Disorders/Diseases: Hair thinning is a symptom of immunological disorders and some infections.
Treat Hair Thinning with the Power of Exosomes
Exosomes, tiny particles in our bodies, contain a plethora of biomolecules.
They enter the nearby cells and manipulate their biochemical process in favor of repair and recovery. Exosomes work on diverse cells as well as the hair cycle. The hair cycle can be divided into three phases- the anagen/growth phase (shows growth), the catagen/transition phase (cells at the base of the hair shaft die to prepare for hair shedding), and the telogen/resting phase (hair sheds out and no growth occurs). Just to be clear, the follicle is the part of the hair strand that is present within the skin, whereas the shaft is the visible part of the strand. Following are the ways exosome treatment forms healthier hair.
Hair Follicle Regeneration
Suppress Cell Death: Cellular distress leads to the activation of the mechanism of cell death or senescence. Exosomes suppress these pathways with their unique bioactive composition.
Increase Stem Cells: The follicle has its own set of stem cells that are required for commencing a new cycle. But their quantity diminishes over time. Exosomes induce the expansion of stem cell number and also activate the dermal papillary cells. These cells go in the direction of the follicle stem cells and cause them to proliferate.
Regulation of the Hair Cycle
Anagen Phase: A number of variables may contribute to the cycle’s disruption. The follicles move earlier than normal from the anagen phase to the subsequent phase. The length of the strand reduces as the anagen phase gets shorter owing to less time for growth. The shorter hair shed out more easily and soon only the empty pore of the strand is left. Exosomes extend this anagen phase, increasing the hair density and forming longer hair.
Thicker Hair
Augment Bulb Size: The follicle has a bulb region in its root. During thinning, this region decreases in diameter. Exosome treatment enhances the diameter of this area and stimulates the multiplication of dermal papillary cells for thicker hair.
Boost the Scalp Health
Enhance Blood Circulation: The quantity of blood vessels in the scalp declines with age. The low supply and the subsequent lack of nutrition and oxygen cause more cells to die. However, exosomes contain growth factors such as vascular endothelial growth factor (VEGF). They initiate the formation of more blood vessels. Elevated blood supply assists in cell growth and multiplication.
Antioxidant: Reactive oxygen species (ROS) are chemical by-products of cellular biochemical reactions. Although cells have their own antioxidants to scavenge these ROS, they don’t suffice in case of excessive ROS accumulation. The chemically reactive ROS damages the cell components, eventually leading to cell death. Exosomes consume ROS and prevent any further damage to the cell.
Anti-Inflammation: Thinning can also result from aberrant immune response or inflammation. The immune cells damage the follicle cells. Exosomes regulate the immune response by their cytokines. They also polarize the immune cells towards healing processes.
Advancexo Exosomes: Tapping the Potential of Exosomes
Advancexo is the manufacturer of exosomes in India. The scientists at Advancexo have developed a Hair Rejuve Kit for addressing hair issues. The kit contains a vial of exosomes and another vial of bioactivating solution. In addition to the already present components of exosomes, the team of Advacexo has packed the exosomes with several other proteins to boost their benefits. Table 1 provides the details of those proteins.
Proteins | The Effects of Proteins in Hair Growth |
Insulin-like growth factor-binding protein 3 | Hair Cycle Regulation |
Hornerin, Fibrinogen beta chain, Myosin-10 | Hair Follicle Regeneration |
Coactosin like protein, Collagen alpha 2 (VI) chain | Improve Hair Health |
Talin-1 | Maintain Hair Follicle Integrity |
Type II cytoskeletal keratin, Keratin Type I and II, Insulin-like growth factor binding protein 5 | Hair Growth |
Vinculin | Promote Stem Cell Proliferation |
Plasminogen activator inhibitor 1, Actin | Promote Blood Vessel Formation |
Collagen alpha1(VI) chain | Build Hair Proteins |
Table 1. The table lists the proteins packed in Advancexo exosomes and their corresponding effects on hair growth
Stepping up for Exosome Therapy
If you are worried for exosome treatment, then don’t worry. The exosome treatment procedure is relatively simple and can be divided into the following steps.
Step 1: Go for a Consultation from a Dermatologist-Dermatologists assess your medical condition and evaluate the underlying reason for thinning.
Step 2: Preparation before the Treatment-Treatment area of scalp is cleansed followed by application of a topical numbing cream is topically applied to anesthetize the region.
Step 3: The Final Treatment-The lyophilized exosome powder is dissolved in the bioactivating solution. This exosome solution is then injected using a fine needle. It is performed in the area of the scalp with thinning to maximize growth.
Step 4: After therapy-The dermatologist provides a few instructions, like avoid washing hair for a certain time period. Follow the instructions for maximum benefits.
Step 5: Ensure timely Follow-up-The therapy takes more than one session, depending on your hair condition. Follow up on time to assess the effects of the therapy.
Who can benefit from the therapy?
Apart from thinning, exosome therapy can also be used to treat bald patches.
Alopecia Areata: It is an immune disorder where the body’s immune cells push the follicle out of the anagen phase, causing substantial hair loss.
Androgenetic Alopecia: Triggered by genetic factors and the hormone disorder, it is the most common form of hair loss.
Traction Alopecia: It is another form of hair loss occurring due to tight hairstyles.
Telogen Effluvium: It is a frequent form of hair thinning. However, it is temporary in nature and occurs due to stress, illness, and nutritional deficiency.
The Bottom Line
Exosome therapy for hair thinning has brought a new era of dermatology. To address the hair loss issues, Advancexo has created an advanced formulation of exosomes – Hair Rejuve Kit. The team at Advancexo strives to give better results. Thus, it has added more proteins in the exosomes to maximize its potential. The hair follicle regeneration with exosomes considerably improves scalp health, resulting in longer, stronger, and thicker hair.
FAQs
Several factors contribute to hair thinning, including age, genes, environment, stress, diet, diseases, etc. At an early stage of thinning, it is better to manage one’s lifestyle to reduce further damage.
Exosomes act on diverse aspects of the issue and improve scalp health by triggering cell proliferation, extending the growth phase, increasing blood vessels, reducing inflammation, augmenting bulb size, etc.
The number of sessions will depend on the type of hair thinning issue you have.
One can achieve substantial hair growth and increased hair density with exosome treatment.
